Substituted Ureas and Their Analogs Containing Framework Fragments: I. 1-(4-Hydroxyadamantan-1-yl)-3-(fluoro/chlorophenyl)ureas

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2024年11月1日

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D. V. Danilov,
V. S. D’yachenko,
D. M. Zapravdina,
E. S. Ilyina,
E. K. Degtyarenko,
V. V. Burmistrov

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Abstract

A series of 1,3-disubstituted ureas containing a 4-(hydroxyadamantan-1-yl)-fragment were synthesized in yields of 55–87% by the reaction of 1-(4-oxoadamantan-1-yl)-3-(halophenyl)ureas with sodium borohydride . The synthesized ureas are potential metabolites and promising soluble human epoxide hydrolase inhibitors.