Synthesis, Crystal Structure, and Antibacterial Activity of N-(2-Chlorobenzyl)-3-methylbut-2-enamide

N-(2-Сhlorobenzyl)-3-methylbut-2-enamide was synthesized, and its structure was determined by single crystal X-ray diffraction and other spectroscopic methods. The compound crystallized in P-1 space group of the triclinic crystal system with the following unit cell parameters: a = 8.8767(5), b = 10.2535(6), c = 13.8768(7) Å; α = 98.608(4)°, β = 103.920(4)°, γ = 98.298(4)°; Z = 4; d_calc = 1.248 g/cm³; V = 1190.54(12) ų. Preliminary antibacterial tests showed that N-(2-chlorobenzyl)-3-methylbut-2-enamide exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 0.01 and 0.02 g/mL, respectively. However, this compound has no obvious bacteriostatic effect on Enterobacter aerogenes.