Efficient Synthesis of 8-Fluoro-10-methyl-3,4-dihydrobenzo[b][1,6]naphthyridine-2(1H)-carboxamides and Their Cytotoxic Activity
摘要
Abstract
A facile synthesis of a new series of 8-fluoro-10-methyl-3,4-dihydrobenzo[b][1,6]naphthyridine-2(1H)-carboxamide hybrids in high yields has been developed via coupling reaction. The synthesized compounds were evaluated for their in vitro anticancer activity against a panel of four human tumor cell lines, viz., MCF-7 (breast cancer), A-549 (lung cancer), OVACR-3 (ovarian cancer) and HeLa (cervical cancer). Compounds 12a, 12c, 12e, 12h, and 12l demonstrated higher activity than that of cisplatin taken as positive control.