Synthesis of a Misoprostol Analogue, 11-Deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B₁ Ethyl Ester

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发表日期：

2024年9月1日

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N. A. Ivanova,
G. A. Shavaleeva,
L. V. Spirikhin,
M. S. Miftakhov

摘要

Abstract

1,2-Addition of lithiated 4-hydroxy-4,5-dimethylhept-1-yne to the keto group of ethyl 7-(5-oxocyclopent-1-en-1-yl)heptanoate, followed by in situ oxidative isomerization of the adduct afforded 11-deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B₁ (PGB₁) ethyl ester.

Synthesis of a Misoprostol Analogue, 11-Deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B1 Ethyl Ester

摘要

Synthesis of a Misoprostol Analogue, 11-Deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B₁ Ethyl Ester