Reaction of 5-Hydroxypyrazolidine with Thiol-Containing Hydrazides as a Route to Biologically Active Ligands for Gold Glyconanoparticles
摘要
Abstract
The reaction of (3S)-1-acetyl-5-hydroxy-2-phenyl-3-methylpyrazolidine with 6-mercaptohexanoic and 11-mercaptoundecanoic acid hydrazides gives in 60–65% yields (3S)-1-acetyl-5-[(ω-mercaptoacyl)hydrazino]-2-phenyl-3-methylpyrazolidines, promising coligands for preparing gold glyconanoparticles for the biomedical purpose.