Synthesis and Study of the Biological Activity of New Compounds Derived from 4-(5-Phenyl-1,3,4-oxadiazole-2-yl)aniline

A new series of N-acyl derivatives (4a–4d) and Azetidin-2-one derivatives (5a, 5b) containing a 1,3,4-oxadiazole ring were prepared by sequence reactions. The new Schiff bases (3a–3d) used as starting materials were prepared via condensation of (4-(5-phenyl-1,3,4-oxadiazole-2yl)aniline) with four replaced aromatic dialdehyde (2a–2d). The newly synthesized Schiff bases (3a–3d) reacted with, acetyl chloride in the dry benzene to get new derivatives (4a–4d). While the second path was towards the formation of new Azetidin-2-one derivatives (5a, 5b) from cyclization reaction of the Schiff bases with chloroacetylchloride in dioxan and triethylamine at 0–5°C. Synthesized compounds had been characterized by FT-IR and ¹H NMR spectra in order to elucidate their structures. Finally, the resulting products were evaluated for it is efficacy measurements against two types of bacteria showed excellent to good efficacy antibacterial activity.