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Application of the ANRORC Process for Directional Synthesis of 5-Ureido-2-pyrazolines as Biologically Active Co-Ligand of Gold Glyco-Nanoparticles

  • 期刊论文

  • 发表日期：

    2024年7月1日

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  • A. Y. Ershov,
  • A. A. Martynenkov,
  • I. V. Lagoda,
  • A. A. Batyrenko

摘要

Abstract

Interaction of 1-phenyl-4,6-dimethylpyrimidine-2(1H)-one with 4-mercaptobuturic acid hydrazide proceeds as ANRORC (Addition of the Nucleophile–Ring Opening–Ring Closure) process and results in the formation with 60% yield of 1-(4-mercaptobutanoyl)-3,5-dimethyl-5-(3-phenylcarbamoylamino)-2-pyrazoline as promising сo-ligand for the preparation of gold glyco-nanoparticles for biomedical purposes.