Synthesis, Antibacterial Activity, and Molecular Docking Study of Chalcones Containing a Thiazolidine-2,4-dione Moiety

A rise in infections caused by methicillin- and vancomycin-resistant Staphylococcus aureus is an increasing global health concern that causes boosting illness and death. The growing problem of drug resistance has emphasized the need to discover and develop new antibacterial agents that work through different mechanisms. To address this issue and create prospective antibacterial drugs, numerous chalcone derivatives of thiazolidine-2,4-dione have been designed, synthesized, and evaluated against three bacterial strains and one fungal strain. Compounds 7a, 7h, and 7k were found to selectively inhibit S. aureus at a concentration of 25 μg/mL but were inactive toward gram-negative bacteria.