Synthesis, Reactions, and Biological Activity of Benzo[h][1,6]naphthyridine Derivatives

Benzo[h][1,6]naphthyridine derivatives are imperative synthetic targets that display a variety of interesting biological activities, including anti-Alzheimer, anticancer, antimalarial, and antiparasitic activities. Despite the interesting findings on these compounds, the literature lacks a comprehensive summary of the synthetic methodologies and pharmacological applications of benzo[h][1,6]naphthyridine derivatives. This review deals with recent advances in the benzonaphthyridine chemistry by discussing various synthetic methods utilized for the preparation of benzo[h][1,6]naphthyridine derivatives which possess promising biological properties. It also gives an updated vision of their most common reactions and the utilization of these derivatives as units for several biologically active compounds.