Synthesis of Ethyl 4-Aryl-2-imino-1-(2-methoxyphenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-oxopiperidine-3-carboxylates
摘要
Abstract
The reaction of ethyl 3-aryl-2-cyanoprop-2-enoates with N1,N3-bis(2-methoxyphenyl)propanediamide afforded previously unknown products of intramolecular heterocyclization of the primary Michael adducts, ethyl 4-aryl-2-imino-1-(2-methoxyphenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-oxopiperidine-3-carboxylates, in 73–90% yields. The product structure was determined by IR and NMR (1H, 13C) spectroscopy.