Expedient Synthesis of Coumarin–1,2,3-Triazole Hybrids via Click Chemistry and Their Antimicrobial Evaluation

This study focuses on the synthesis of aromatic and heteroaromatic triazole derivatives known for their versatile therapeutic potential in the treatment of cancer, bacterial infections, fungal infections, and malaria. To achieve this, we have developed an efficient synthetic pathway for a wide range of derivatives with a structural motif represented as 2-(4-{[(2-oxo-2H-chromen-4-yl)oxy]methyl}-1H-1,2,3-triazol-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide. The structure of the synthesized compounds was determined using ¹H and ¹³C NMR spectroscopy, FT-IR spectroscopy, mass spectrometry, and elemental analysis. Furthermore, this study delves into the antimicrobial and antifungal properties of the coumarin-linked triazole derivatives, highlighting their potential as diverse chemotherapeutic agents with promising clinical applications. Also, the in silico study was performed to assess pharmacokinetics and toxicity profiles.