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One-Pot Approach to N-Benzenesulfonyl Amino Acid Esters That Enhance Proline Content in Response to Excess Cadmium

  • 期刊论文

  • 发表日期：

    2024年4月1日

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  • Z. Y. Huang,
  • X. H. Li,
  • P. Yang,
  • L. J. Chen,
  • X. J. Yang

摘要

Abstract

N-Benzenesulfonyl amino acid esters have drawn much attention due to their pharmacological and biological activity. Herein, a facile and effective one-pot approach to N-benzenesulfonyl amino acid esters has been developed, and 16 compounds have been obtained in excellent yields (90–95%) in a short time (9–14 min) using 4-bromobenzenethiol and amino acid esters as starting materials. Significantly, methyl 2-(4-bromoben­zene­sulfon­amido)acetate (3a) could enhance the proline content of soybean in response to excess cadmium in a way similar to the plant hormone abscisic acid.