Synthesis of Spiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidines] by Reaction of Pyrrolobenzoxazinetriones with 6-Amino-1,3-dimethyluracil

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发表日期：

2024年4月1日

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A. I. Kobelev,
M. V. Dmitriev,
A. N. Maslivets

摘要

Abstract

3-Aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones reacted with 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-diones to give 3-aroyl-4-hydroxy-1-(2-hydroxyaryl)-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidine]-2′,4′,5,6′(1H,1′H,3′H,7′H)-tetraones. The product structure was confirmed by X-ray analysis. The described reaction provides a simple route to the difficultly accessible spiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidine] heterocyclic system.