Synthesis and Antiviral Activity of New Dimeric 1,2,3-Triazolyl Pyrimidine Nucleoside Analogues

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发表日期：

2024年4月1日

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O. V. Andreeva,
L. F. Saifina,
M. M. Shulaeva,
M. G. Belenok,
V. V. Zarubaev,
A. V. Slita,
A. S. Volobueva,
V. E. Semenov,
V. E. Kataev

摘要

Abstract

A series of new dimers of pyrimidine nucleoside analogues have been synthesized. The dimers are composed of two uracil or thymine fragments linked at N³ through a polymethylene bridge and bearing a β-D-ribofuranose residue linked to N¹ of the nucleobase through a 1,2,3-triazolylalkyl spacer. Biological screening revealed that some of the synthesized dimers are active against influenza A (H1N1) virus and coxsackievirus B3 with IC₅₀ values of 13 and 4.5 μM, respectively.