Synthesis and Anti-inflammatory, Analgesic, and Antipyretic Activities of Azomethine Derivatives of the Tetrahydropyran Series

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发表日期：

2024年3月1日

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A. U. Isakhanyan,
N. Z. Hakobyan,
R. E. Muradyan,
H. E. Tumajyan,
H. A. Panosyan,
A. A. Harutyunyan

摘要

Abstract

Schiff bases of the tetrahydropyran series have been synthesized by the condensation of 2-(tetrahydropyran-4-yl)ethanamines and tetrahydropyran-4-amine with 4-chloro, 4-fluoro-, and 4-(dimethylamino)benzaldehydes and thiophene-2-carbaldehyde. The synthesized compounds showed lower anti-inflammatory, analgesic, and antipyretic activities than those of diclofenac and indomethacin used as reference drugs.