Synthesis of Amides Based on Biologically Active (5Z,9Z)-Eicosa-5,9-dienoic Acid

期刊论文
发表日期：

2024年3月1日

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E. Kh. Makarova,
A. A. Makarov,
U. M. Dzhemilev,
V. A. D’yakonov

摘要

Abstract

New amides of (5Z,9Z)-eicosa-5,9-dienoic acid, which is a highly active topoisomerase I/II inhibitor, were synthesized via Cp₂TiCl₂-catalyzed intermolecular cross-cyclomagnesiation of aliphatic and oxygen-containing 1,2-dienes as the key step.