Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: XIX. exo-Isomers of N-(1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl)-N′-R-ureas and -thioureas

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发表日期：

2024年3月1日

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V. V. Burmistrov,
Ya. P. Kuznetsov,
V. V. Novikov,
M. H. Saeef Abbas,
A. V. Davidenko,
A. A. Vernigora,
G. M. Butov

摘要

Abstract

N,N′-Disubstituted ureas and thioureas containing a 1,1,7-trimethylbicyclo[2.2.1]heptan-2-yl substituent were synthesized in up to 99% yields by the reaction of exo-(R or S)-1,1,7-trimethylbicyclo[2.2.1]heptan-2-amine with aromatic isocyanates and isothiocyanates with the goal of comprehensive estimation of enantiomeric stereospecificity of human soluble epoxide hydrolase (hsEH). The synthesized compounds are promising hsEH inhibitors.