Recent Catalytic Routes to 3-Azabicyclo[3.1.0]hexane Derivatives
摘要
Abstract
The review summarizes recent advances in the synthesis of 3-azabicyclo[3.1.0]hexane (3-ABH) derivatives that are heterocyclic systems often present in molecules capable of acting on various biological targets and actively used in drug design. Modern synthetic approaches to 3-ABH derivatives based on transition metal catalysis have been classified and analyzed, and mechanisms of the key processes have been considered. The examined approaches include the synthesis of 3-ABH by three- and five-membered ring fusion, as well as numerous one-pot syntheses from acyclic precursors via tandem cyclizations.