Ag-TiO2 Nanocomposite: An Efficient Heterogeneous and Reusable Catalyst for the Three-Component Synthesis of 1-Amidoalkyl-2-naphthols under Solvent-Free Conditions
摘要
Abstract
1-Amidoalkyl-2-naphthol derivatives have been synthesized via solvent-free three-component reaction between various aldehydes, β-naphthol, and urea or benzamide by using 2 mol % of Ag-TiO2 nanocomposite as an efficient benign heterogeneous catalyst at 110°C. The catalyst was easily recycled and reused up to three times without significant loss in activity. The proposed method provides significant benefits, including benign conditions, atom economy, low amount of the catalyst, the use of low-cost, accessible, and recyclable nanocomposite catalyst, and no need of chromatographic purification of the target products.