Microwave-Assisted Synthesis and Evaluation of Bis[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] 7,8′-Methylenebis[2-(E)-(benzylideneamino)-4H-chromene-3-carboxylates] as Potent Antimicrobial Agents

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发表日期：

2024年1月1日

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A. Srinivas,
S. Rajitha,
E. Kalyan Rao,
K. Sindhura,
S. I. Farheen,
G. Chandrakala,
S. Sultana

摘要

Abstract

A series of novel bis[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] 7,8′-methylenebis[2-(E)-(benzylideneamino)-4H-chromene-3-carboxylates] 6a–6f were synthesized from di(prop-2-yn-1-yl) 7,8′-methylenebis[(E)-2-(benzylideneamino)-4H-chromene-3-carboxylates] 5a–5f via a one-pot procedure involving 1,3-dipolar cycloaddition catalyzed by CuSO₄ and glucose under microwave irradiation at 100°C as a key step. Compounds 6d and 6f bearing 4-NO₂ and 4-OH groups exhibited good activity against some fungal strains, and compounds 6b and 6f bearing 4-Cl and 4-OH groups exhibited good antimicrobial activity against S. pyogenes, E. coli, B. subtilis, and S. aureus.