Efficient Synthesis, Antibacterial Activity, and Molecular Docking Study of N-{2-[7-(1,3-Benzoxazol-2-yl)-3-hydroxyquinoxaline-2-carbonyl]hydrazinecarbonothioyl}benzamide Derivatives

期刊论文
发表日期：

2024年1月1日

查看全文

L. Eppakayala,
R. Madipelly,
S. Kasula,
R. Domala,
M. Bucha

摘要

Abstract

A series of benzamide derivatives containing quinoxaline and benzoxazole fragments were synthesized and characterized by ¹H NMR and mass spectra. The antibacterial activity of the synthesized derivatives was tested in vitro against gram-positive and gram-negative bacterial strains using an agar well diffusion assay. The molecular docking study showed good docking scores between –9.85 and –7.8 kcal/mol against DNA gyrase (PDB ID: 4KTN).