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Abstract <p>Six membered heterocyclic derivatives (dihydroquinazoline-4-one and 1,3-benzothiazine-4-one (<b>6–15</b>)) were synthesized by cyclization reaction of Schiff bases (<b>1</b>–<b>5</b>) with anthranilic acid and <i>o</i>-mercaptobenzoic acid in oily bath. Prepared compounds was characterized by FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass spectroscopy and elemental analysis to confirm structure of synthesized derivatives. Heterocyclic compounds are of interest for scientific research due to important antioxidant properties; Compounds <b>10</b>, <b>12</b>, and<b> 15</b> appeared good results by scavenging free radicals. Investigation of microbial activity to synthesized compounds <b>6–15</b> showed that compounds <b>6</b>,<b> 10</b>, and<b> 11</b> demonstrate the highest inhibition zone.</p>

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Synthesis, Characterization, and Evaluation of Biological Activity of Dihydroquinazoline-4-one and 1,3-Benzothiazine-4-one Derivatives

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Wasan K. Damdoom,
  • Oday H. R. Al-Jeilawi,
  • Maha D. Azeez

摘要

Abstract

Six membered heterocyclic derivatives (dihydroquinazoline-4-one and 1,3-benzothiazine-4-one (6–15)) were synthesized by cyclization reaction of Schiff bases (1–5) with anthranilic acid and o-mercaptobenzoic acid in oily bath. Prepared compounds was characterized by FTIR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis to confirm structure of synthesized derivatives. Heterocyclic compounds are of interest for scientific research due to important antioxidant properties; Compounds 10, 12, and 15 appeared good results by scavenging free radicals. Investigation of microbial activity to synthesized compounds 6–15 showed that compounds 6, 10, and 11 demonstrate the highest inhibition zone.