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Abstract <p>Quaternary ammonium salts (QAS) containing <i>gem</i>-dichlorocyclopropane and 1,3-dioxacycloalkane moieties were synthesized (40–90% yields) based on pyridine, hexamethylenetetramine, and tertiary amines. The structure of the obtained salts was confirmed by <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy data. The antibacterial activity of the QAS against bacterial strains (<i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>S. aureus</i>, and <i>Acinetobacter baumannii</i>) was evaluated. The study showed that among the series of salts there are “leader” compounds exhibiting high antibacterial activity.</p>

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Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • G. Z. Raskil’dina,
  • Yu. G. Borisova,
  • A. N. Vereshchagin,
  • E. V. Detusheva,
  • R. M. Sultanova,
  • S. S. Zlotskii

摘要

Abstract

Quaternary ammonium salts (QAS) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane moieties were synthesized (40–90% yields) based on pyridine, hexamethylenetetramine, and tertiary amines. The structure of the obtained salts was confirmed by 1H and 13C NMR spectroscopy data. The antibacterial activity of the QAS against bacterial strains (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinetobacter baumannii) was evaluated. The study showed that among the series of salts there are “leader” compounds exhibiting high antibacterial activity.