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Abstract <p>In this study, a series of new <i>O</i>,<i>O</i>-dialkyl(1-hydroxy-1-(4-nitrophenyl)ethyl)phosphonates containing various substituents on the phosphorus atom were designed. All synthesized compounds demonstrated antibacterial and antifungal activity against gram-positive bacterial strains <i>B. cereus</i> and <i>S. aureus</i>. It was found that compounds <b>2–5</b> exhibit antifungal activity comparable to the control compound Naftifine hydrochloride.</p>

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Synthesis, In Vitro Antibacterial and Antifungal Evaluations of O,O-Dialkyl(1-hydroxy-1-(4-nitrophenyl)ethyl)phosphonates

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • R. R. Davletshin,
  • A. N. Sedov,
  • M. P. Shulaeva,
  • K. A. Ivshin,
  • N. V. Davletshina,
  • A. V. Gerasimov,
  • S. V. Mosunova,
  • P. A. Kuryntseva,
  • O. K. Pozdeev

摘要

Abstract

In this study, a series of new O,O-dialkyl(1-hydroxy-1-(4-nitrophenyl)ethyl)phosphonates containing various substituents on the phosphorus atom were designed. All synthesized compounds demonstrated antibacterial and antifungal activity against gram-positive bacterial strains B. cereus and S. aureus. It was found that compounds 2–5 exhibit antifungal activity comparable to the control compound Naftifine hydrochloride.