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Abstract <p>The principal nitrogenous metabolite of proteins is the urea linkage, which is an important structural component in many bio-active compounds. The hydrogen bonding capacity and metabolic stability of the –NH–CO–NH– moiety have resulted in its insertion in potent urea and ureidopeptide conjugates and bioactive oligomers. Comparatively, these molecules are more inflexible due to strong hydrogen bonding properties and possess greater metabolic constancy, along with improved pharmacokinetic properties such as absorption, transport characteristics and low toxicity. It is our intention that the present work provides a succinct exploration of the synthesis of the ureas and ureidopeptides.</p>

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A Brief Review on the Synthetic Methodologies of Potent Ureas and Ureidopeptides

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • H. S. Lalithamba,
  • Aisha Siddekha,
  • M. Ramya,
  • G. K. Prashanth,
  • G. Nagendra

摘要

Abstract

The principal nitrogenous metabolite of proteins is the urea linkage, which is an important structural component in many bio-active compounds. The hydrogen bonding capacity and metabolic stability of the –NH–CO–NH– moiety have resulted in its insertion in potent urea and ureidopeptide conjugates and bioactive oligomers. Comparatively, these molecules are more inflexible due to strong hydrogen bonding properties and possess greater metabolic constancy, along with improved pharmacokinetic properties such as absorption, transport characteristics and low toxicity. It is our intention that the present work provides a succinct exploration of the synthesis of the ureas and ureidopeptides.