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Abstract <p>The acylation of phenols and their cycloalkylated derivatives with acetyl chloride in the presence of the KU-23 catalyst was examined. The main regularities and the reaction mechanism of phenol acylation were analyzed, with particular attention to factors affecting product yield and selectivity, as well as the features governing C- and O-acylation pathways. The acylation of 1-(methylcyclopentyl)phenol with acetyl chloride was investigated as a model reaction. The influence of key kinetic parameters, including temperature, reagent molar ratio, reaction time, and catalyst loading, on the yield of the target product and process selectivity was evaluated. The temperature range studied was 120–160°C, the reaction time was 4–8 h, the molar ratio of <i>p</i>-(1-methylcyclopentyl)phenol to acetyl chloride varied from 1 : 1 to 1 : 3, and the catalyst loading ranged from 5 to 15% relative to the cyclopentylphenol. The structure of the synthesized compound was confirmed by IR and NMR spectroscopy, and its physicochemical properties were determined. Optimal conditions for the acylation of <i>p</i>-(1-methylcyclopentyl)phenol with acetyl chloride in the presence of the KU-23 catalyst were identified as follows: temperature 145°C, reaction time 6 h, molar ratio of <i>p</i>-cycloalkylphenol to acetyl chloride 1 : 2, and catalyst loading 10%. Under these conditions, the yield of the target product reached 70.3%, with a selectivity of 82.6%.</p>

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Acylation of p-(1-Methylcyclopentyl)phenol with Acetyl Chloride in the Presence of KU-23 Catalyst

  • 期刊论文

  • 发表日期：

    2026年4月18日

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  • Chingiz Knyaz Rasulov,
  • Gunay Zaman Heydarli

摘要

Abstract

The acylation of phenols and their cycloalkylated derivatives with acetyl chloride in the presence of the KU-23 catalyst was examined. The main regularities and the reaction mechanism of phenol acylation were analyzed, with particular attention to factors affecting product yield and selectivity, as well as the features governing C- and O-acylation pathways. The acylation of 1-(methylcyclopentyl)phenol with acetyl chloride was investigated as a model reaction. The influence of key kinetic parameters, including temperature, reagent molar ratio, reaction time, and catalyst loading, on the yield of the target product and process selectivity was evaluated. The temperature range studied was 120–160°C, the reaction time was 4–8 h, the molar ratio of p-(1-methylcyclopentyl)phenol to acetyl chloride varied from 1 : 1 to 1 : 3, and the catalyst loading ranged from 5 to 15% relative to the cyclopentylphenol. The structure of the synthesized compound was confirmed by IR and NMR spectroscopy, and its physicochemical properties were determined. Optimal conditions for the acylation of p-(1-methylcyclopentyl)phenol with acetyl chloride in the presence of the KU-23 catalyst were identified as follows: temperature 145°C, reaction time 6 h, molar ratio of p-cycloalkylphenol to acetyl chloride 1 : 2, and catalyst loading 10%. Under these conditions, the yield of the target product reached 70.3%, with a selectivity of 82.6%.