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Abstract <p>Two different design of conjugates of prostate specific membrane antigen (PSMA) ligands with monomethyl auristatin E were proposed. PSMA ligands were obtained using peptide synthesis approaches. The possibility of obtaining bimodal conjugates of these ligands with two equivalents of monomethyl auristatin E by the azide-alkyne cycloaddition reaction was shown. The possibility of obtaining compounds containing only one equivalent of monomethyl auristatin E in the structure by these methods was analyzed.</p>

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Approaches to the Synthesis of Double Conjugates of PSMA Ligands with Monomethyl Auristatin E

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Nikolai Yu. Zyk,
  • Nina S. Boutakova,
  • Elizaveta A. Ivanova,
  • Elena K. Beloglazkina,
  • Aleksei E. Machulkin

摘要

Abstract

Two different design of conjugates of prostate specific membrane antigen (PSMA) ligands with monomethyl auristatin E were proposed. PSMA ligands were obtained using peptide synthesis approaches. The possibility of obtaining bimodal conjugates of these ligands with two equivalents of monomethyl auristatin E by the azide-alkyne cycloaddition reaction was shown. The possibility of obtaining compounds containing only one equivalent of monomethyl auristatin E in the structure by these methods was analyzed.