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Abstract <p>Nowadays there is a pressing need for the development of novel anticancer agents that are capable of functioning as theranostics. We report the development of a novel Pt(IV) prodrug with light-controllable mode of antitumor activity. The complex demonstrated absorption in the NIR region &gt;860 nm, which potentially enables fluorescent visualization of deep tumors. The ability of the Pt(IV) prodrug to inhibit tumor cell viability was investigated. The complex was demonstrated efficient intracellular accumulation and absence of cell death via necrosis. Our findings demonstrate the remarkable potential of employing fluorescent dyes with the capacity to absorb deep NIR wavelengths in the development of novel, effective anticancer agents with theranostic mode of action.</p>

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Novel Pt(IV) Prodrug with Long-Wavelength Absorption in the NIR Range

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Daniil Spector,
  • Anastasia Zharova,
  • Vladislav Bykusov,
  • Roman Akasov,
  • Maxim Stepanov,
  • Vladimir Kuzmin,
  • Anton Egorov,
  • Ivan Burtsev,
  • Elena Beloglazkina,
  • Olga Krasnovskaya

摘要

Abstract

Nowadays there is a pressing need for the development of novel anticancer agents that are capable of functioning as theranostics. We report the development of a novel Pt(IV) prodrug with light-controllable mode of antitumor activity. The complex demonstrated absorption in the NIR region >860 nm, which potentially enables fluorescent visualization of deep tumors. The ability of the Pt(IV) prodrug to inhibit tumor cell viability was investigated. The complex was demonstrated efficient intracellular accumulation and absence of cell death via necrosis. Our findings demonstrate the remarkable potential of employing fluorescent dyes with the capacity to absorb deep NIR wavelengths in the development of novel, effective anticancer agents with theranostic mode of action.