Abstract <p>The review summarizes and analyzes the literature data on methods for the preparation of D,L-homocysteine-thiolactone hydrochloride and its enantiomers. Due to the lack of comprehensive reviews on the topic and the limited number of synthetic approaches, the authors considered it necessary to systematize and describe the available data on the synthetic methods for D,L-homocysteine-thiolactone hydrochloride and its enantiomers, covering the period from the 1930s onward. An assessment of productivity, reagent availability, and environmental safety of the considered methods is provided.</p>