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Abstract <p>Nitrosyl complexes of tetrahedral iron—nitric oxide (NO) donors—with 5-substituted 1,3,4-oxadiazole-2-thiols were obtained for the first time. According to elemental analysis data, spectral methods, and quantum chemical calculations, there are paramagnetic tetrairon nitrosyl complexes of the μ-NCS structural type. The NO-donor properties and the effect of the obtained compounds on phosphodiesterase (PDE) activity were studied. It was shown that the synthesized complexes exhibit effective PDE inhibitory activity.</p>

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Novel Nitrosyl Complexes of Tetrahedral Iron with 5-Substituted 1,3,4-Oxadiazole-2-thiols

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Evgeniya A. Syreyshchikova,
  • Svyatoslav Ya. Gadomsky,
  • Maxim A. Blagov,
  • Alexander V. Kulikov,
  • Olesya V. Pokidova,
  • Nataliya A. Sanina,
  • Sergey M. Aldoshin

摘要

Abstract

Nitrosyl complexes of tetrahedral iron—nitric oxide (NO) donors—with 5-substituted 1,3,4-oxadiazole-2-thiols were obtained for the first time. According to elemental analysis data, spectral methods, and quantum chemical calculations, there are paramagnetic tetrairon nitrosyl complexes of the μ-NCS structural type. The NO-donor properties and the effect of the obtained compounds on phosphodiesterase (PDE) activity were studied. It was shown that the synthesized complexes exhibit effective PDE inhibitory activity.