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Abstract <p>Alkylation of phthalimide with α,ω-dibromoalkanes in dimethylformamide in the presence of anhydrous potassium carbonate afforded a series of α,ω-diphthalimidoalkanes. Their subsequent hydrolysis in a potassium hydroxide solution, steam distillation of the diamine bases, and neutralization of the distillate with hydrochloric acid yielded the target α,ω-diaminoalkanes as dihydrochlorides with overall yields of 90–96%.</p>

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Effective Synthesis of α,ω-Diaminoalkanes by the Optimized Gabriel Method

  • 期刊论文

  • 发表日期：

    2026年3月11日

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  • Mikhail A. Barabanov,
  • Georgy S. Martyanov,
  • Alexander V. Pestov

摘要

Abstract

Alkylation of phthalimide with α,ω-dibromoalkanes in dimethylformamide in the presence of anhydrous potassium carbonate afforded a series of α,ω-diphthalimidoalkanes. Their subsequent hydrolysis in a potassium hydroxide solution, steam distillation of the diamine bases, and neutralization of the distillate with hydrochloric acid yielded the target α,ω-diaminoalkanes as dihydrochlorides with overall yields of 90–96%.