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Abstract <p>A facile and selective synthesis method for 2-phenylpyridine derivatives was proposed through C–H bond arylation. Readily available phenols can be employed as proelectrophiles in direct arylations, inexpensive Ni(acac)<sub>2</sub> as the catalyst, and moderate to excellent yields were achieved for the coupling reactions. This protocol is simple, efficient, and applicable to various substituted 2-phenylpyridine derivatives.</p>

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Nickel-Catalyzed Direct Arylation by C–H/C–O Cleavage with Phenol

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • He Zhang

摘要

Abstract

A facile and selective synthesis method for 2-phenylpyridine derivatives was proposed through C–H bond arylation. Readily available phenols can be employed as proelectrophiles in direct arylations, inexpensive Ni(acac)2 as the catalyst, and moderate to excellent yields were achieved for the coupling reactions. This protocol is simple, efficient, and applicable to various substituted 2-phenylpyridine derivatives.