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Abstract <p>An effective approach was developed to the synthesis of dicarbazoles and carbazole–tetrahydrocarbazole hybrids tethered via di- or triethylene glycol spacers. These polyether spacers are susceptible to metabolic cleavage, enabling targeted delivery of the bioactive moiety to functionally important enzyme active sites.</p>

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Synthesis of Dicarbazoles and Carbazole-(2,3,4,9-tetrahydro-1H-carbazoles) Linked by Polyether Spacers

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • Alexey Yu. Aksinenko,
  • Tatiana V. Goreva,
  • Tatiana A. Epishina,
  • Sergei O. Bachurin

摘要

Abstract

An effective approach was developed to the synthesis of dicarbazoles and carbazole–tetrahydrocarbazole hybrids tethered via di- or triethylene glycol spacers. These polyether spacers are susceptible to metabolic cleavage, enabling targeted delivery of the bioactive moiety to functionally important enzyme active sites.