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Abstract <p>Derivatives of pyridoxine and 3-hydroxypyridine containing azidomethyl groups at various positions of the pyridine ring have been synthesized. The synthesized compounds exhibit high antimycotic activity against reference and clinical strains of mycelial and yeast fungi, which exceeds the activity of the known drug fluconazole. The cytotoxic properties of the obtained compounds against conditionally normal and tumor cell lines, as well as the acute toxicity of the lead compound in mice, have been investigated.</p>

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Synthesis and Biological Activity of Azidomethyl Derivatives of Pyridoxine and 3-Hydroxypyridine

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • E. A. Platonova,
  • R. M. Khaziev,
  • S. A. Lisovskaya,
  • O. V. Bondar,
  • A. D. Mukhametova,
  • R. R. Kazakova,
  • R. M. Vafina,
  • D. Yu. Grishaev,
  • O. I. Gnezdilov,
  • E. I. Romanova,
  • Yu. G. Shtyrlin

摘要

Abstract

Derivatives of pyridoxine and 3-hydroxypyridine containing azidomethyl groups at various positions of the pyridine ring have been synthesized. The synthesized compounds exhibit high antimycotic activity against reference and clinical strains of mycelial and yeast fungi, which exceeds the activity of the known drug fluconazole. The cytotoxic properties of the obtained compounds against conditionally normal and tumor cell lines, as well as the acute toxicity of the lead compound in mice, have been investigated.