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Abstract <p>The review summarizes data on the synthesis methods and properties of 4-amino-5-oxoproline derivatives, including those with substituents at the amino and/or carboxyl group, carbon skeleton atoms, as well as peptides incorporating a 4-amino-5-oxoproline fragment. Particular attention is paid to the synthesis methods of the individual stereoisomers of derivatives of this amino acid, which serve as starting materials for constructing more complex structures such as peptidomimetics, etc. 4-Amino-5-oxoproline derivatives exhibit a variety of biological activities: antitumor, immunomodulatory, psychotropic, etc., and are of interest for the development of new therapeutic agents based on them.</p>

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Synthesis and Properties of 4-Amino-5-oxoproline Derivatives (A Review)

  • 期刊论文

  • 发表日期：

    2026年2月24日

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  • Aleksey Yu. Vigorov,
  • Marina A. Korolyova,
  • Galina L. Levit,
  • Victor P. Krasnov

摘要

Abstract

The review summarizes data on the synthesis methods and properties of 4-amino-5-oxoproline derivatives, including those with substituents at the amino and/or carboxyl group, carbon skeleton atoms, as well as peptides incorporating a 4-amino-5-oxoproline fragment. Particular attention is paid to the synthesis methods of the individual stereoisomers of derivatives of this amino acid, which serve as starting materials for constructing more complex structures such as peptidomimetics, etc. 4-Amino-5-oxoproline derivatives exhibit a variety of biological activities: antitumor, immunomodulatory, psychotropic, etc., and are of interest for the development of new therapeutic agents based on them.