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Abstract <p>The synthesis of substituted 1-{[(<i>E</i>)-benzylidene]amino}-3-{[(1<i>E</i>,2<i>E</i>)-2-(hydroxyimino)-1,2-diphenylethylidene]amino}-4-imino-6-(methylthio)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles was carried out by reacting 2-[bis(methylthio)methylene]malononitrile with (2<i>Z</i>)-<i>N'</i>-[(<i>E</i>)-benzylidene-2-(2-hydroxyimino)-1,2-diphenylethylidene]hydrazine-1-carbothiohydrazide derivatives in dimethyl formamide using anhydrous potassium carbonate. By replacing the methylthio group of new compounds with nitrogen nucleophiles, derivatives were produced. The structure was confirmed by spectral analysis. The newly formed compounds were tested with bacterial and fungal strains. The results obtained by the molecular docking study are in good agreement with the practical analysis of antimicrobial activities.</p>

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A Novel Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carbonitrile Derivatives as an Antimicrobial Agent

  • 期刊论文

  • 发表日期：

    2026年5月2日

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  • Mahesh Auti,
  • Mayur Gawande,
  • Nilesh Halikar,
  • Abdulsaud Abdul Mannan Khan,
  • Sambhaji P. Vartale

摘要

Abstract

The synthesis of substituted 1-{[(E)-benzylidene]amino}-3-{[(1E,2E)-2-(hydroxyimino)-1,2-diphenylethylidene]amino}-4-imino-6-(methylthio)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles was carried out by reacting 2-[bis(methylthio)methylene]malononitrile with (2Z)-N'-[(E)-benzylidene-2-(2-hydroxyimino)-1,2-diphenylethylidene]hydrazine-1-carbothiohydrazide derivatives in dimethyl formamide using anhydrous potassium carbonate. By replacing the methylthio group of new compounds with nitrogen nucleophiles, derivatives were produced. The structure was confirmed by spectral analysis. The newly formed compounds were tested with bacterial and fungal strains. The results obtained by the molecular docking study are in good agreement with the practical analysis of antimicrobial activities.