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Abstract <p>Protection of the aldehyde group of 2-(alkylthio)-4,6-dichloro-pyrimidine-5-carbaldehydes changes the selectivity of their reaction with arylhydrazines, which is apparently associated with a steric hindrances and change in the sequence of interaction of these compounds. In this work, the effect of the protective group and the structure of arylhydrazine on the reaction result was studied. The reaction conditions were optimized and a series of 6-(alkylthio)-2-aryl-<i>2H</i>-pyrazolo[3,4-<i>d</i>]pyrimidines without impurity of isomer 1 were obtained in good yields.</p>

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Synthesis of 6-(Alkylthio)-2-aryl-2H-pyrazolo[3,4-d]pyrimidines

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • E. S. Ofitserova,
  • A. A. Shklyarenko,
  • V. A. Tafeenko,
  • L. V. Myznikov

摘要

Abstract

Protection of the aldehyde group of 2-(alkylthio)-4,6-dichloro-pyrimidine-5-carbaldehydes changes the selectivity of their reaction with arylhydrazines, which is apparently associated with a steric hindrances and change in the sequence of interaction of these compounds. In this work, the effect of the protective group and the structure of arylhydrazine on the reaction result was studied. The reaction conditions were optimized and a series of 6-(alkylthio)-2-aryl-2H-pyrazolo[3,4-d]pyrimidines without impurity of isomer 1 were obtained in good yields.