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Abstract <p>A nickel-catalyzed cross-coupling reaction between unactivated difluorosubstituted aromatic ketones and aryltitanium reagents in the presence of a ligand and LiCl as an additive is reported, showing excellent <i>ortho</i>-selectivity. The reaction exhibits good functional group tolerance and a wide substrate range, providing medium to high yields of the <i>ortho</i>-arylated products.</p>

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Nickel-Catalyzed ortho-Selective Cross-Coupling Reaction of Unactivated Difluoroaromatic Ketones with Aryltitanium–LiCl Reagents

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Xiaoyun He

摘要

Abstract

A nickel-catalyzed cross-coupling reaction between unactivated difluorosubstituted aromatic ketones and aryltitanium reagents in the presence of a ligand and LiCl as an additive is reported, showing excellent ortho-selectivity. The reaction exhibits good functional group tolerance and a wide substrate range, providing medium to high yields of the ortho-arylated products.