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Abstract <p>New compounds—[4-hydroxy-2,6-bis-(3-methoxyphenyl)-4-phenylcyclohexane-1,3-diyl]bis(phenylmethanone), 4′′-methoxy-5′-oxo-<i>N</i>-phenyl-2′,3′,4′,5′-tetrahydro-[1,1′:3′,1′′-terphenyl]-4′-carboxamide, and 4′′-nitro-5′-oxo-<i>N</i>-phenyl-2′,3′,4′,5′-tetrahydro-[1,1′:3′,1′′-terphenyl]-4′-carboxamide—were synthesized by the reaction of acetophenone with aldehydes and acetoacetanilide. Subsequently, their antibacterial activity against pathogenic bacteria was studied. The structure of the products was determined using NMR spectroscopy. A probable reaction mechanism for the formation of the six-membered ring was proposed.</p>

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Synthesis and Antibacterial Activity of Some Acetophenone Derivatives

  • 期刊论文

  • 发表日期：

    2026年4月28日

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  • Ibrahim G. Mamedov,
  • Farid N. Naghiyev,
  • Nurana F. Aliyeva,
  • Victor N. Khrustalev,
  • Khudaverdi G. Ganbarov

摘要

Abstract

New compounds—[4-hydroxy-2,6-bis-(3-methoxyphenyl)-4-phenylcyclohexane-1,3-diyl]bis(phenylmethanone), 4′′-methoxy-5′-oxo-N-phenyl-2′,3′,4′,5′-tetrahydro-[1,1′:3′,1′′-terphenyl]-4′-carboxamide, and 4′′-nitro-5′-oxo-N-phenyl-2′,3′,4′,5′-tetrahydro-[1,1′:3′,1′′-terphenyl]-4′-carboxamide—were synthesized by the reaction of acetophenone with aldehydes and acetoacetanilide. Subsequently, their antibacterial activity against pathogenic bacteria was studied. The structure of the products was determined using NMR spectroscopy. A probable reaction mechanism for the formation of the six-membered ring was proposed.