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Abstract <p>A series of pyridine-based 1,2,3-triazole derivatives were synthesized using both microwave-assisted and conventional methods employing green solvents in the presence of CuSO<sub>4</sub> as a catalyst. The synthesized compounds were thoroughly characterized by <sup>1</sup>H, <sup>13</sup>C NMR, IR, and mass spectroscopic techniques to confirm their structural identities. Furthermore, all compounds were evaluated for their anticancer and antimicrobial activities. Most of the synthesized derivatives exhibited significant biological activity, demonstrating both anticancer and antimicrobial potential. Most of the compounds displayed exceptional cytotoxic activity against the tested cancer cell lines and showed strong inhibitory effects against all evaluated bacterial and fungal strains, indicating their broad-spectrum biological efficacy.</p>

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Microwave-Assisted Synthesis of Pyridine-Based Triazole Derivatives and Their Anticancer and Antimicrobial Activity

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Karra Amarender,
  • Pogaku Bhadraiah,
  • Thotla Krishna,
  • Yagnam Swetha,
  • Adem Kurumanna,
  • Sachin Kumar,
  • Praveen Chandra Jha,
  • Mone Radhika

摘要

Abstract

A series of pyridine-based 1,2,3-triazole derivatives were synthesized using both microwave-assisted and conventional methods employing green solvents in the presence of CuSO4 as a catalyst. The synthesized compounds were thoroughly characterized by 1H, 13C NMR, IR, and mass spectroscopic techniques to confirm their structural identities. Furthermore, all compounds were evaluated for their anticancer and antimicrobial activities. Most of the synthesized derivatives exhibited significant biological activity, demonstrating both anticancer and antimicrobial potential. Most of the compounds displayed exceptional cytotoxic activity against the tested cancer cell lines and showed strong inhibitory effects against all evaluated bacterial and fungal strains, indicating their broad-spectrum biological efficacy.