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Abstract <p>Phthalimides, a significant group of biologically active nitrogen-containing heterocycles, are widely present in pharmaceuticals, natural compounds, agrochemicals, polymers, and dyes. Additionally, they play a vital role as key intermediates in various organic transformations. A novel, straightforward, and practical one-pot synthetic approach has been developed for the preparation of phthalimide derivatives via a condensation reaction between aryl iodides and anilines, employing zinc acetate as a catalyst and DBU as a base in 1,4-dioxane as the solvent. This one-pot protocol provides these valuable desired compounds under mild conditions with excellent efficiency by using simple available starting materials. All the synthesized compounds screened for in vitro antibacterial activity against gram-positive and gram-negative strains.</p>

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Zinc-Catalyzed Ligand-Free Double Carbonylation Reactions for the Synthesis of Phthalimide Derivatives and Their In Vitro Antibacterial Evaluation

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Kamalaker Reddy Kamireddy,
  • Hussain Shaik

摘要

Abstract

Phthalimides, a significant group of biologically active nitrogen-containing heterocycles, are widely present in pharmaceuticals, natural compounds, agrochemicals, polymers, and dyes. Additionally, they play a vital role as key intermediates in various organic transformations. A novel, straightforward, and practical one-pot synthetic approach has been developed for the preparation of phthalimide derivatives via a condensation reaction between aryl iodides and anilines, employing zinc acetate as a catalyst and DBU as a base in 1,4-dioxane as the solvent. This one-pot protocol provides these valuable desired compounds under mild conditions with excellent efficiency by using simple available starting materials. All the synthesized compounds screened for in vitro antibacterial activity against gram-positive and gram-negative strains.