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Abstract <p>(<i>Z</i>)-4-Arylidenehexahydro-2<i>H</i>-pyrido[1,2-<i>a</i>]pyrazin-3(4<i>H</i>)-ones were synthesized starting from (<i>Z</i>)-4-arylidene-2-phenyl-1,3-oxazol-5(4<i>H</i>)-ones and piperidin-2- ylmethanamine, and optimal conditions for their synthesis were found. It was found that (<i>Z</i>)-arylidenehexahydro-2<i>H</i>-pyrido[1,2-<i>a</i>]pyrazin-3-(4<i>H</i>)-ones undergo cleavage in an acidic medium to form 2-piperidylmethylamides of 2-oxopropionic acids. UV spectra, mass-spectra and anticholinesterase properties of the synthesized compounds were studied.</p>

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Synthesis and Some Properties of (Z)-4-Arylidenehexahydropyrido[1,2-a]pyrazin-3(4H)-ones

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • A. A. Hovhannisyan,
  • A. G. Agababyan,
  • A. T. Makichyan,
  • A. A. Shahkhatuni,
  • A. M. Davinyan,
  • E. A. Hakobyan,
  • V. O. Topuzyan,
  • L. Kh. Galstyan

摘要

Abstract

(Z)-4-Arylidenehexahydro-2H-pyrido[1,2-a]pyrazin-3(4H)-ones were synthesized starting from (Z)-4-arylidene-2-phenyl-1,3-oxazol-5(4H)-ones and piperidin-2- ylmethanamine, and optimal conditions for their synthesis were found. It was found that (Z)-arylidenehexahydro-2H-pyrido[1,2-a]pyrazin-3-(4H)-ones undergo cleavage in an acidic medium to form 2-piperidylmethylamides of 2-oxopropionic acids. UV spectra, mass-spectra and anticholinesterase properties of the synthesized compounds were studied.