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Abstract <p>An efficient method was developed for the synthesis of fused nitrogen-containing heterocyclic compounds, such as 1,3,4-oxadiazole-substituted pyrazolines based on 3,5-disubstituted pyrazoline acylhydrazide. <i>N</i>′-Acetyl- and <i>N</i>′-chloroacetyl derivatives were obtained by acylation of previously synthesized 2-[3-methyl-5-(morpholinomethyl)pyrazoline]acetohydrazide with acetic and monochloroacetic acids chlorides. Intramolecular cyclization of the synthesized pyrazoline derivatives under the action of phosphorus chloride furnished 1,3,4-oxadiazole-substituted pyrazolines.</p>

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Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • A. R. Karayeva,
  • M. I. Shatirova,
  • G. M. Mamedova,
  • Sh. K. Sheydayeva

摘要

Abstract

An efficient method was developed for the synthesis of fused nitrogen-containing heterocyclic compounds, such as 1,3,4-oxadiazole-substituted pyrazolines based on 3,5-disubstituted pyrazoline acylhydrazide. N′-Acetyl- and N′-chloroacetyl derivatives were obtained by acylation of previously synthesized 2-[3-methyl-5-(morpholinomethyl)pyrazoline]acetohydrazide with acetic and monochloroacetic acids chlorides. Intramolecular cyclization of the synthesized pyrazoline derivatives under the action of phosphorus chloride furnished 1,3,4-oxadiazole-substituted pyrazolines.