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Abstract <p>A library of fifteen triazolyl nucleosides was synthesized by regioselective [3+2] cycloaddition reaction between azido nucleoside and various chalcones under thermal condition in the presence of catalyst tetrabutyl ammonium hydrogen sulfate. All synthesized compounds were evaluated antifungal activity against two phytopathogenic fungi <i>Sclerotium rolfsii</i> and <i>Rhizoctonia solani</i>. Most of the compounds demonstrated good to moderate activity against fungi.</p>

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Synthesis and Antifungal Activity of 4-Aroyl-5-aryl-1-(thymin-5ʹ-yl)triazoles

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Chandra Kant,
  • Uday Mishra,
  • Saheban Khan,
  • Jaynath Kumar,
  • Madhulata Shukla,
  • Ravi Bhushan Pathak,
  • Indu Chopra,
  • Ram Kumar,
  • Rajesh Kumar

摘要

Abstract

A library of fifteen triazolyl nucleosides was synthesized by regioselective [3+2] cycloaddition reaction between azido nucleoside and various chalcones under thermal condition in the presence of catalyst tetrabutyl ammonium hydrogen sulfate. All synthesized compounds were evaluated antifungal activity against two phytopathogenic fungi Sclerotium rolfsii and Rhizoctonia solani. Most of the compounds demonstrated good to moderate activity against fungi.