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Abstract <p>A novel dual-wavelength fluorescent probe targeting hypochlorite was successfully designed and synthesized, with its molecular structure unambiguously characterized by <sup>1</sup>H, <sup>13</sup>C NMR spectroscopy and high-resolution mass spectrometry. This “off-on” type sensor demonstrates a distinctive dual-emission response at 494 and 599 nm upon hypochlorite activation. The proposed response mechanism, involving hypochlorite-induced specific structural modulation, not only achieves remarkable target specificity but also effectively suppresses background interference through its ratiometric detection modality. Importantly, both emission channels exhibit excellent linear correlations (R<sup>2</sup> &gt; 0.995) with hypochlorite concentrations in the biologically relevant range of 50–180 μM, demonstrating its potential for quantitative analysis in complex matrices.</p>

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An Effective Dual-Wavelength Fluorescent Sensor for ClO− Detection

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Yichen Xu,
  • Ming Yue,
  • Yun-Hui Zhao,
  • Zilong Tang,
  • Tao Guo

摘要

Abstract

A novel dual-wavelength fluorescent probe targeting hypochlorite was successfully designed and synthesized, with its molecular structure unambiguously characterized by 1H, 13C NMR spectroscopy and high-resolution mass spectrometry. This “off-on” type sensor demonstrates a distinctive dual-emission response at 494 and 599 nm upon hypochlorite activation. The proposed response mechanism, involving hypochlorite-induced specific structural modulation, not only achieves remarkable target specificity but also effectively suppresses background interference through its ratiometric detection modality. Importantly, both emission channels exhibit excellent linear correlations (R2 > 0.995) with hypochlorite concentrations in the biologically relevant range of 50–180 μM, demonstrating its potential for quantitative analysis in complex matrices.