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Abstract <p>(<i>E</i>)-Azomethines were synthesized in 70–77% yields by condensation of rimantadine, 4-aminoantipyrine, and streptocide with propargyl ethers of hydroxybenzaldehydes. Varying the mutual arrangement of the pharmacophoric groups linked via hydroxybenzaldehyde linkers allows to form structures of various geometries. Using two propargyl-containing azomethines (4-aminoantipyrine derivatives) as an example, 1,4-disubstituted 1,2,3-triazoles were obtained under the conditions of the Cu(I)-catalyzed azide-alkyne cycloaddition reaction.</p>

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Propargyl-Containing Derivatives of Remantadine, 4-Aminoantipyrine and Streptocide Linked by Hydroxybenzaldehyde Linkers

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • E. A. Dikusar,
  • E. N. Margun,
  • E. A. Akishina,
  • I. A. Kolesnik,
  • S. S. Kovalskaya,
  • H. Zhou,
  • V. I. Potkin

摘要

Abstract

(E)-Azomethines were synthesized in 70–77% yields by condensation of rimantadine, 4-aminoantipyrine, and streptocide with propargyl ethers of hydroxybenzaldehydes. Varying the mutual arrangement of the pharmacophoric groups linked via hydroxybenzaldehyde linkers allows to form structures of various geometries. Using two propargyl-containing azomethines (4-aminoantipyrine derivatives) as an example, 1,4-disubstituted 1,2,3-triazoles were obtained under the conditions of the Cu(I)-catalyzed azide-alkyne cycloaddition reaction.