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Abstract <p>An effective approach was developed for the synthesis of a number of pyrazole derivatives of ricinoleic acid, available from natural castor oil. Transesterification of the ricinoleic acid triglyceride to its methyl ester, oxidation to a keto derivative, and acid isomerization resulted in a single α,β-unsaturated ketone of the <i>E</i>-configuration, whose reaction with a number of hydrazides completed the synthesis.</p>

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Synthesis of Potentially Biologically Active Pyrazole Derivatives of Ricinoleic Acid

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • G. Y. Ishmuratov,
  • M. P. Yakovleva,
  • I. S. Nazarov,
  • K. M. Saitov

摘要

Abstract

An effective approach was developed for the synthesis of a number of pyrazole derivatives of ricinoleic acid, available from natural castor oil. Transesterification of the ricinoleic acid triglyceride to its methyl ester, oxidation to a keto derivative, and acid isomerization resulted in a single α,β-unsaturated ketone of the E-configuration, whose reaction with a number of hydrazides completed the synthesis.