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Abstract <p>The reaction of primary amines of different nature (benzylamine and aniline) with sodium azide and ethyl orthoformate in acetic acid, leading to the corresponding 1R-1<i>H</i>-tetrazoles (R = PhCH<sub>2</sub>, Ph) has been studied by gas chromatography–mass spectrometry. The key intermediates of this reaction, formed as a result of nucleophilic substitution of the ethoxy groups in ethyl orthoformate, as well as acylation of the initial amines in the reaction medium, have been elucidated.</p>

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A Study of the Synthesis of 1-R-1H-Tetrazoles from Primary Amines, Sodium Azide, and Ethyl Orthoformate by Gas Chromatography–Mass Spectrometry

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • E. D. Motuz,
  • R. E. Trifonov

摘要

Abstract

The reaction of primary amines of different nature (benzylamine and aniline) with sodium azide and ethyl orthoformate in acetic acid, leading to the corresponding 1R-1H-tetrazoles (R = PhCH2, Ph) has been studied by gas chromatography–mass spectrometry. The key intermediates of this reaction, formed as a result of nucleophilic substitution of the ethoxy groups in ethyl orthoformate, as well as acylation of the initial amines in the reaction medium, have been elucidated.