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Abstract <p>New 8-amino-10-methyl-3-azaspiro[5.5]undeca-8,10-dien-7,7,9-tricarbonitriles were synthesized in 72 and 67% yields by condensation of <i>N</i>-benzyl- or <i>N</i>-ethyl-4-piperidone with malononitrile and acetone in ethanol in the presence of morpholine. The molecular and crystal structures of 8-amino-3-benzyl-10-methyl-3-azaspiro[5.5]undeca-8,10-dien-7,7,9-tricarbonitrile were studied by single crystal X-ray diffraction analysis.</p>

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Pseudo Four-Component Cyclocondensation of N-Alkylpiperidin-4-ones, Malononitrile, and Acetone

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • S. G. Krivokolysko,
  • V. V. Dotsenko,
  • N. A. Aksenov,
  • I. V. Aksenova

摘要

Abstract

New 8-amino-10-methyl-3-azaspiro[5.5]undeca-8,10-dien-7,7,9-tricarbonitriles were synthesized in 72 and 67% yields by condensation of N-benzyl- or N-ethyl-4-piperidone with malononitrile and acetone in ethanol in the presence of morpholine. The molecular and crystal structures of 8-amino-3-benzyl-10-methyl-3-azaspiro[5.5]undeca-8,10-dien-7,7,9-tricarbonitrile were studied by single crystal X-ray diffraction analysis.