Scholarlink

Abstract <p>It was found that the Reformatsky reagents, obtained from methyl-1-bromocyclobutane-, 1-bromocyclopentane-, and 1-bromocyclohexanecarboxylates and zinc, react with diimines, derived from ethylenediamine and aromatic aldehydes, in a 2 : 1 molar ratio to form the corresponding bis(spiroazetidin-2-ones). The structure of the obtained compounds was confirmed by single crystal X-ray diffraction analysis. The in vivo analgesic activity of the synthesized compounds was assessed and shown to have pronounced effects, which exceeded those of the reference drug (sodium metamizole).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis and Analgesic Activity of N,N′-(Ethane-1,2-diyl)bis(spiroazetidin-2ones) Containing Cyclobutane, Cyclopentane or Cyclohexane Fragments

  • 期刊论文

  • 发表日期：

    2025年7月1日

查看全文
  • E. A. Nikiforova,
  • L. A. Vasilenko,
  • R. R. Makhmudov,
  • D. P. Zverev,
  • M. V. Dmitriev,
  • D. V. Baibarodskikh,
  • N. F. Kirillov

摘要

Abstract

It was found that the Reformatsky reagents, obtained from methyl-1-bromocyclobutane-, 1-bromocyclopentane-, and 1-bromocyclohexanecarboxylates and zinc, react with diimines, derived from ethylenediamine and aromatic aldehydes, in a 2 : 1 molar ratio to form the corresponding bis(spiroazetidin-2-ones). The structure of the obtained compounds was confirmed by single crystal X-ray diffraction analysis. The in vivo analgesic activity of the synthesized compounds was assessed and shown to have pronounced effects, which exceeded those of the reference drug (sodium metamizole).